منابع مشابه
Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells
Centrioles are composed of long-lived microtubules arranged in nine triplets. However, the contribution of triplet microtubules to mammalian centriole formation and stability is unknown. Little is known of the mechanism of triplet microtubule formation, but experiments in unicellular eukaryotes indicate that delta-tubulin and epsilon-tubulin, two less-studied tubulin family members, are require...
متن کاملCentriole Replication
This paper describes the replication of centrioles during spermatogenesis in the Prosobranch snail, Viviparus malleatus Reeve. Sections for electron microscopy were cut from pieces of testis fixed in OsO(4) and embedded in the polyester resin Vestopal W. Two kinds of spermatocytes are present. These give rise to typical uniflagellate sperm carrying the haploid number of 9 chromosomes, and atypi...
متن کاملCentriole structure.
Centrioles are among the largest protein-based structures found in most cell types, measuring approximately 250 nm in diameter and approximately 500 nm long in vertebrate cells. Here, we briefly review ultrastructural observations about centrioles and associated structures. At the core of most centrioles is a microtubule scaffold formed from a radial array of nine triplet microtubules. Beyond t...
متن کاملRevisiting the role of the mother centriole in centriole biogenesis.
Centrioles duplicate once in each cell division cycle through so-called templated or canonical duplication. SAK, also called PLK4 (SAK/PLK4), a kinase implicated in tumor development, is an upstream regulator of canonical biogenesis necessary for centriole formation. We found that overexpression of SAK/PLK4 could induce amplification of centrioles in Drosophila embryos and their de novo formati...
متن کاملSnapShot: Centriole Biogenesis
an d d up lic at io n SPD2 (Ce, Dm)/ CEP192 (Hs) No centriole duplication (Ce); <PCM recruited (Ce, Dm, and Hs); no basal body duplication (Dm) Asterless (Dm)/ CEP152 (Dr, Hs) Aberrant PCM recruitment (Dm) and centriole duplication (Dm and Dr) γ-Tubulin (Dm, Hs, Tt, Pt)/TBG (Ce) Aberrant centriole duplication (Ce, Hs, Tt), centriole structure and separation (Pt, Dm) Overexpression: de novo form...
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ژورنال
عنوان ژورنال: Prion
سال: 2008
ISSN: 1933-6896,1933-690X
DOI: 10.4161/pri.2.1.5064